Suchen und Finden
Autoantibodies
von: Yehuda Shoenfeld, M. Eric Gershwin, M.E. Gershwin, Pier Luigi Meroni
Elsevier Reference Monographs, 2011
ISBN: 9780080467238 , 872 Seiten
2. Auflage
Format: PDF, ePUB
Kopierschutz: DRM
Preis: 165,00 EUR
Title Page
4
Copyright Page
5
Table of Contents
8
Foreword
16
Preface
20
About the Editors
22
List of Contributors
24
Introduction
34
Part I Introduction: Autoantibodies-Unique Characteristics
36
Chapter 1 What is an Autoantibody?
38
Abstract
38
Introduction
38
Characterization of autoimmune diseases
39
Tolerance
39
Concluding remarks
40
References
40
Chapter 2 Natural Autoantibodies, Heralding, Protecting and Inducing Autoimmunity
42
Abstract
42
Historical notes
42
The origin of NAbs
43
NAbs and autoimmunity
44
NAbs and the innate immune system
44
Apoptosis and NAbs
45
Protective NAbs
45
References
47
Chapter 3 Molecular Mimicry
48
Abstract
48
Historical notes
48
Forms of molecular mimicry
49
Natural autoantibodies and molecular mimicry
51
Animal model of molecular mimicry
52
Clinical utility
52
Conclusion
53
References
54
Chapter 4 Affinity and Avidity of Autoantibodies
56
Abstract
56
Historical notes
56
Avidity and affinity
57
Clinical utility in autoimmune disorders
61
Take-home messages
62
References
63
Chapter 5 Pathogenic Mechanisms and Clinical Relevance of Autoantibodies
64
Abstract
64
Introduction
64
Cell surface binding and lysis (cytotoxicity)
65
Binding to cell surface receptors without cytolysis
66
Immune complex–mediated damage
67
Translocation of intracellular antigens to cell membrane
68
Penetration into living cells
69
Binding to extracellular molecules
69
Take-home messages
70
References
70
Chapter 6 Native Autoantigens Versus Recombinant Autoantigens
72
Abstract
72
Introduction
72
Detection of autoantibodies
73
ELISA
73
Native autoantigens
75
Recombinant autoantigens
76
Criteria for usage of autoantigens in immunoassays
78
Limitations of recombinant technology for the production of autoantigens
79
Acknowledgements
79
Take-home messages
79
References
79
Chapter 7 Redox-Reactive Autoantibodies
82
Abstract
82
Historical notes
83
Autoantigens
83
Autoantibodies
84
Acknowledgements
87
Take-home messages
87
References
87
Chapter 8 Predictive Autoantibodies
90
Abstract
90
Introduction
90
Prediction of disease
91
Prediction of specific clinical manifestations
91
Hierarchy of autoantibodies
92
Combining HLA and predictive antibodies in prediction
93
Combining specific genes and antibody testing
93
Implications and future directions
93
Take-home messages
95
References
95
Chapter 9 Autoantibody Subclasses
96
Abstract
96
Historical notes
96
The findings
97
The methods
100
The causes
100
The consequences
101
Conclusion
101
References
102
Chapter 10 Idiotypes and Anti-Idiotypes
104
Abstract
104
Historical notes
105
The autoantigen(s)
105
Structure of idiotypes
106
Genetics
106
Autoantibodies
106
Physiologic role
107
Pathogenic role
107
Clinical utility
109
Summary
110
Take-home messages
110
References
111
Chapter 11 Novel Diagnostic Methods for Autoantibody Detection
112
Abstract
112
The use of single autoantibody tests in the diagnosis and classification of autoimmune diseases: The ‘old’ technologies
113
Multiplex technologies for the study of autoantibody profiles: The ‘new’ technologies
113
The predictive role of autoantibody profiles
116
Take-home messages
116
References
117
Part II Allergic Disease Autoantibodies
118
Chapter 12 Human IgE–Specific Autoantibodies and Autoantibodies to IgE Receptors
120
Summary
120
Human IgE
121
IgE receptors
124
Antibodies to IgE receptors
125
Take-home messages
126
References
126
Part III Antineutrophil Antibodies
128
Chapter 13 Antineutrophil Cytoplasmic Autoantibodies with Specificity for Myeloperoxidase
130
Abstract
130
Historical notes
131
The autoantigen
131
The autoantibodies
133
Clinical utility
135
Take-home messages
137
References
137
Chapter 14 Antineutrophil Cytoplasmic Autoantibodies with Specificity for Proteinase 3
140
Abstract
140
Historical notes
141
Autoantigen
141
Autoantibody
142
Clinical utility
143
Take-home messages
144
References
144
Chapter 15 Neutrophil-Specific Antinuclear and Anti-cytoplasmic Antibodies in Chronic Inflammatory Diseases
146
Abstract
146
Historical notes
147
Autoantigens
147
Autoantibody
148
Clinical utility and prognostic value
149
Conclusions
151
References
151
Chapter 16 Antineutrophil Cytoplasmatic Autoantibodies with Specificity to Proteinase 3
154
Abstract
154
Historical notes
155
Autoantigens
155
The autoantibodies
156
Clinical utility
159
Take-home messages
161
References
161
Part IV Introduction: Antinuclear Antibodies
162
Chapter 17 Antinuclear Antibodies: General Introduction
164
Abstract
164
Historical notes
164
Autoantigens
165
Autoantibodies
165
Take-home messages
167
References
168
Chapter 18 Antinucleolar Antibodies
170
Abstract
170
Historical notes
170
Autoantigen
171
Autoantibodies
171
Conclusion
173
Take-home messages
174
References
174
Chapter 19 Anti-Chromatin (Nucleosome) Autoantibodies
176
Abstract
176
Historical notes
177
Autoantigen
177
Autoantibody
178
Clinical utility
180
Conclusion
183
Take-home messages
183
References
183
Chapter 20 Centromere Autoantibodies
186
Abstract
186
Historical notes
186
Autoantigen
187
Autoantibody
189
Methods of detection
190
Clinical utility
190
Take-home messages
192
References
192
Chapter 21 dsDNA Autoantibodies
194
Abstract
194
Historical notes
195
Autoantigen
195
Autoantibody
196
Clinical utility
199
References
202
Chapter 22 Histone Autoantibodies
204
Abstract
204
Historical notes
204
The autoantigens
205
Autoantibodies
208
Clinical utility
210
Take-home messages
211
References
211
Chapter 23 Ku and Ki Autoantibodies
212
Summary
212
Historical notes
212
Autoantigens
213
Autoantibodies
215
Clinical utility
216
Take-home messages
219
References
219
Chapter 24 Neuronal Nuclear Autoantibodies, Type 1 (Hu)
220
Abstract
220
Historical notes
221
Autoantigens
221
Autoantibody
222
Clinical utility
223
Take-home messages
225
References
225
Chapter 25 Nuclear Envelope Protein Autoantibodies/Antilamin Autoantibodies
226
Summary
226
Historical notes
227
Autoantigens
227
Autoantibody
229
Take-home messages
230
References
230
Chapter 26 Anti-Nucleosome Autoantibodies
232
Abstract
232
Historical notes
233
Autoantigen
233
Autoantibody
234
Clinical utility
236
Take-home messages
238
References
238
Chapter 27 Proliferating Cell Nuclear Antigen Autoantibodies
240
Historical notes
240
Autoantigens
241
Autoantibodies
242
Clinical utility
243
Conclusion
245
Acknowledgements
245
References
245
Chapter 28 Anti-RA33 Antibodies (Antibodies to the Heterogeneous Nuclear Ribonucleoprotein A2)
246
Abstract
246
Historical notes
247
Autoantigen
247
Autoantibody
248
Clinical utility
249
Take-home messages
250
References
250
Chapter 29 Anti-Ribosomal P Antibodies
252
Abstract
252
Autoantigen
252
Autoantibody
253
Assays for anti-rib-P Ab detection
254
Serological test performance
256
Clinical studies
256
Conclusion
257
Take-home messages
257
References
257
Chapter 30 SS-A (Ro) Autoantibodies
260
Historical notes
260
Autoantigen
260
Autoantibodies
262
Clinical utility
264
Conclusion
264
References
265
Chapter 31 Topoisomerase-I (Scl-70) Autoantibodies
266
Abstract
266
Historical notes
267
Autoantigen
267
Autoantibody
268
Clinical utility
271
Take-home messages
272
References
272
Chapter 32 SS-B (La) Autoantibodies
274
Abstract
274
Historical notes
274
Autoantigen
275
Autoantibody
277
Clinical utility
279
Take-home messages
280
References
281
Chapter 33 Anti-RNA Polymerase III Antibodies
282
Abstract
282
Historical notes
283
Autoantigen(s)
283
Autoantibody
285
Clinical utility
287
Take-home messages
289
References
289
Part V Autoantibodies to Biologic Factors/Structures
290
Chapter 34 GW Bodies, P Bodies and Components of the miRNA Pathway
292
Abstract
292
Historical notes
292
Autoantigen
293
Autoantibody
295
Clinical utility
295
Take-home messages
296
References
297
Chapter 35 Golgi Complex and Endosome Antibodies
298
Abstract
298
Autoantigen
298
Autoantibody
301
Clinical utility
303
Take-home messages
305
References
305
Chapter 36 p53 Autoantibodies
306
Abstract
306
Historical notes
306
Autoantigen
307
Autoantibody
309
Clinical utility
310
Take-home messages
311
References
311
Chapter 37 Human Antiganglioside Autoantibodies
312
Abstract
312
Historical notes
313
Autoantigens
313
Autoantibody
314
Clinical utility
316
Take-home messages
318
Acknowledgement
318
References
318
Chapter 38 Human Anti-alpha-Galactosyl Antibodies
320
Abstract
320
Historical notes
321
Autoantigen
321
Autoantibody
322
Clinical utility
323
Take-home messages
325
References
325
Chapter 39 Autoantibodies in Therapeutic Preparations of Human Intravenous Immunoglobulin (IVIG)
328
Abstract
328
Historical notes
329
Autoantigens
329
Autoantibodies
329
Clinical utility
331
Take-home messages
332
References
332
Chapter 40 Cytokine Antibodies
334
Abstract
334
Historical notes
335
The autoantigens
336
The autoantibodies
338
Clinical utility
340
Take-home messages
342
Acknowledgement
342
References
342
Chapter 41 Cytoskeletal Autoantibodies/Anti-Actin Antibodies
344
Abstract
344
Historical notes
344
The autoantigen
345
Autoantibody
346
Clinical utility
350
Take-home messages
350
References
351
Chapter 42 Fibrillarin Autoantibodies
352
Abstract
352
Historical notes
352
Autoantigen
353
Autoantibody
354
Clinical utility
356
Take-home messages
358
Acknowledgements
358
References
358
Chapter 43 Fibronectin Autoantibodies
360
Abstract
360
Historical notes
360
Autoantigen
361
Autoantibody
362
Clinical utility
363
Take-home messages
364
References
364
Chapter 44 Interferon-Inducible Protein IFI16 Autoantibodies
366
Abstract
366
Historical notes
366
Autoantigen
367
Autoantibodies
369
Clinical utility
370
Take-home messages
371
References
371
Part VI Cardiac Autoantibodies
374
Chapter 45 Autoantibodies in Atherosclerosis
376
Abstract
376
Introduction
377
Oxidized LDL and antibodies to oxidized LDL
377
Phosphorylcholine and anti-phosphorylcholine antibodies
379
Phospholipids and antiphospholipid antibodies
380
Take-home messages
381
References
381
Chapter 46 Heat Shock Protein Autoantibodies
384
Abstract
384
Historical notes and the autoimmune hypothesis of atherogenesis
384
Autoantigen
385
Take-home messages
388
References
388
Chapter 47 Myocardial Autoantibodies and their Clinical Significance
390
Abstract
390
Historical and general perspective
391
Infectious agents implicated in human DCM
393
Autoantigens identified in sera of IDCM patients
395
Immunogobulin apheresis as a therapeutic option in DCM
397
Clinical relevance of cardiac specific autoantibodies in human DCM
397
Take-home messages
399
References
399
Part VII Endocrine Autoantibodies
402
Chapter 48 Glutamic Acid Decarboxylase Autoantibodies
404
Abstract
404
Historical notes
405
Autoantigen
405
Autoantibody
407
Clinical utility
409
Take-home messages
413
References
413
Chapter 49 Humoral Immunity in Type 1 Diabetes Mellitus
414
Abstract
414
Historical notes
415
Autoantigen
415
Autoantibody
418
Clinical utility
421
Take-home messages
422
References
422
Chapter 50 Antibodies to Adrenal, Gonadal Tissues and Steroidogenic Enzymes
424
Abstract
424
Historical notes
425
Adrenal and gonadal autoantigens
425
Autoantibodies to adrenal cortex and to 21-OH
428
Autoantibodies to gonadal tissue and steroidogenic enzymes (17alpha-OHAbs and P450sccAbs)
432
Take-home messages
434
Acknowledgements
435
References
435
Chapter 51 Thyroglobulin, Thyroperoxidase, and Thyrotropin-Receptor Autoantibodies
438
Historical notes
438
Thyroglobulin antibodies
439
Thyroperoxidase antibodies
442
Clinical utility
443
Thyrotropin-receptor antibodies
445
Take-home messages
448
References
448
Part VIII GI and Liver Autoantibodies
450
Chapter 52 Anti-Intestinal Goblet Cell Antibodies
452
Summary
452
Historical notes
452
Autoantigen
454
Autoantibody
454
Clinical utility
455
Take-home messages
457
References
457
Chapter 53 Tumor-Associated Autoantibodies
458
Summary
458
Historical notes
459
Autoantigenic targets of tumor-associated AAB
459
Relevance of tumor-associated AAB
466
Tumor-associated AAB – Biomarkers for the prediction and early diagnosis of cancer?
467
Take-home messages
469
References
469
Chapter 54 Cryoglobulins and Cryoglobulins Secondary to Hepatitis C Virus Infection
472
Abstract
472
Historical notes
472
Cryoprecipitation
473
Autoantigen
473
Autoantibody
474
Methods of detection
475
Prevalence/prognosis
475
Treatment
475
Take-home messages
476
References
476
Chapter 55 Anti-Tissue Transglutaminase and Anti-Endomyisial Antibodies
478
Abstract
478
Historical notes
479
Autoantigen
479
Autoantibody
480
Clinical utility
482
Take-home messages
485
References
485
Chapter 56 Anti-Gliadin Antibodies
486
Abstract
486
Historical notes
486
The antigen
487
The antibody
488
Clinical utility
489
Take-home messages
491
References
491
Chapter 57 Reticulin Autoantibodies
492
Abstract
492
Historical notes
492
Autoantigen
493
Autoantibody
494
Clinical utility
496
Take-home messages
496
References
497
Chapter 58 Liver Cytosol Antigen Type 1 Autoantibodies, Liver Kidney Microsomal Autoantibodies, and Liver Microsomal Autoantibodies
498
Abstract
498
Liver kidney microsomal autoantibodies and liver microsomal autoantibodies
499
Autoantigen and autoantibody definitions of LKM/LM autoantibodies
499
Hepatitis D-associated microsomal autoantibodies
503
Microsomal autoantibodies in autoimmune hepatitis associated with the autoimmune polyglandular syndrome
503
Microsomal autoantibodies and drug reactions
504
Microsomal autoantibodies of unknown relevance
504
General role of anti-microsomal autoantibodies
504
Liver cytosolic autoantibodies
505
Autoantibody definition and autoantigen
505
Clinical utility
505
Take-home messages
505
References
506
Chapter 59 Antimitochondrial Antibodies
508
Summary
508
Historical notes
508
Autoantigens
509
Autoantibody
509
Clinical utility
510
Take-home messages
511
References
511
Chapter 60 Parietal Cell and Intrinsic Factor Autoantibodies
514
Summary
514
Historical notes
515
Gastric parietal cell autoantigen
515
Gastric parietal cell autoantibody
516
Intrinsic factor autoantigen
516
Intrinsic factor autoantibody
517
Clinical utility
517
Parietal cell antibody
517
Intrinsic factor antibody
518
Take-home messages
520
References
521
Chapter 61 Smooth Muscle Antibodies
522
Abstract
522
Historical notes
522
Autoantigen
523
Autoantibody
523
Clinical utility
524
References
525
Part IX Hematologic Autoantibodies
528
Chapter 62 Coagulation Factor Autoantibodies
530
Abstract
530
Coagulation pathways
530
Historical notes: Autoantibodies to coagulation factor VIII (FVIII)
531
Autoantigen
531
Autoantibody
533
Clinical utility
535
Autoantibodies to other coagulation factors
537
Autoantibodies to von Willebrand factor autoantigen
537
Take-home messages
545
References
545
Chapter 63 Autoantibodies in Heparin-Induced Thrombocytopenia
546
Abstract
546
Historical notes
547
Autoantigen: The heparin–platelet factor 4 complex
547
Autoantibody
549
Clinical utility
551
Take-home messages
553
References
553
Chapter 64 Platelet Autoantibodies
556
Abstract
556
Historical notes
557
Platelet autoantigens
557
ITP
557
Platelet autoantibodies
559
Clinical utility
560
Take-home messages
561
References
561
Chapter 65 Red Cell Autoantibodies
564
Abstract
564
Introduction
565
Autoantigen
565
Clinical utility
568
Take-home messages
569
Acknowledgment
570
References
570
Chapter 66 Lymphocytotoxic Autoantibodies
572
Abstract
572
Historical notes
573
The autoantigen
573
The autoantibodies
575
Clinical utility
577
Clinical parameters
577
Take-home messages
578
References
578
Part X Kidney Autoantibodies
580
Chapter 67 Anti-ATP Synthase Beta-Chain Autoantibodies
582
Abstract
582
Historical notes
582
Autoantigen
583
Autoantibody
583
Clinical utility
585
Take-home messages
587
References
587
Chapter 68 Glomerular Basement Membrane Autoantibodies
588
Abstract
588
Historical notes
588
Autoantigen
589
Autoantibody
590
Clinical utility
592
Take-home messages
593
References
594
Chapter 69 Nephritic Factor Autoantibodies
596
Historical notes
596
The autoantigen
597
Autoantibodies
597
Clinical utility
599
Take-home messages
600
References
600
Part XI Neurological System Autoantibodies
602
Chapter 70 Acetylcholine Receptor and Muscle Specific Kinase Autoantibodies
604
Abstract
604
Historical notes
604
The autoantigen
605
The autoantibody
606
Clinical utility
608
Muscle specific kinase
610
Conclusion
610
References
611
Chapter 71 Myositis Autoantibodies: Aminoacyl-tRNA Synthetase, Signal Recognition Particle, Mi-2, and PM-Scl Autoantibodies
612
Abstract
612
Historical notes
613
Autoantigen
616
Autoantibodies
619
Clinical utility
621
Take-home messages
623
References
623
Chapter 72 Anti-MOG Antibodies
626
Abstract
626
Historical notes
627
Autoantigen
627
Autoantibody
629
Clinical utility
632
Prognostic value
632
Take-home messages
633
References
633
Chapter 73 Antibodies to Hsp 70 in Inner Ear Disease
634
Abstract
634
Historical notes
634
Autoantigen
635
Autoantibody
636
Clinical utility
637
Take-home messages
639
References
639
Chapter 74 Autoantibodies in the Lambert–Eaton Myasthenic Syndrome (LEMS) and Amyotrophic Lateral Sclerosis (ALS)
640
Abstract
640
Historical notes
641
The Lambert–Eaton myasthenic syndrome
641
Amyotrophic lateral sclerosis
641
Autoantigen: Voltage-gated calcium channels
642
Autoantibody
642
Clinical utility
643
Take-home messages
645
References
645
Chapter 75 Ganglioside Autoantibodies
646
Abstract
646
Historical notes
646
The autoantigen(s)
647
Autoantibodies
648
Clinical utility
651
Take-home messages
652
References
653
Chapter 76 Myelin Associated Antibodies: Myelin-Associated Glycoprotein Autoantibodies, Myelin Basic Protein Autoantibodies and Myelin...
654
Abstract
654
Myelin-associated glycoprotein
655
Myelin basic protein and proteolipid protein
656
Conclusions
659
References
660
Chapter 77 Paraneoplastic Neurological Antibodies: Nuclear
662
Abstract
662
Historical notes
663
Autoantigens
663
Autoantibodies
664
Clinical utility
668
Take-home messages
669
References
670
Chapter 78 Paraneoplastic Neurological Antibodies: Purkinje Cell Cytoplasm
672
Abstract
672
Historical notes
673
Autoantigens
673
Autoantibodies
674
Clinical utility
676
Take-home messages
677
References
677
Chapter 79 Paraneoplastic Neurological Antibodies: Additional Reactivities
680
Abstract
680
Historical notes
681
Autoantigens
681
Autoantibodies
682
Clinical utility
685
Take-home messages
687
References
687
Chapter 80 Retinal Autoantibodies
688
Abstract
688
Historical notes
689
Autoantigen
689
Autoantibody
690
Clinical utility
692
Take-home messages
692
References
693
Chapter 81 Autoantibodies in Epilepsy
694
Abstract
694
Historical background
694
Voltage-gated potassium channel antibodies
695
Glutamic acid decarboxylase antibodies
696
Other autoantibodies in epilepsy
698
Conclusions
699
Take-home messages
699
References
699
Part XII Rheumatic Disease Autoantibodies
702
Chapter 82 Anti-Fodrin Antibodies
704
Abstract
704
Autoantigen
704
Autoantibody
705
Clinical utility
706
Take-home messages
709
References
709
Chapter 83 Antibodies to Laminin
710
Abstract
710
Historical notes
710
Autoantigen
711
Autoantibody
712
Clinical utility
713
Take-home messages
714
References
715
Chapter 84 Autoantibodies Against Muscarinic Acetylcholine Receptor in Patients with Sjögren’s Syndrome
716
Abstract
716
Historical notes
717
Autoantigen
717
Autoantibody
717
Clinical utility
718
Take-home messages
719
References
719
Chapter 85 Beta2-Glycoprotein I Autoantibodies
722
Abstract
722
Historical notes
723
The Autoantigen
723
The autoantibodies
724
Clinical utility
726
Take-home messages
727
References
727
Chapter 86 C1 Inhibitor Autoantibodies
730
Abstract
730
Historical notes
730
The Autoantigen
731
The autoantibody
732
Clinical utility
733
Take-home messages
735
References
735
Chapter 87 Autoantibodies to C1q
738
Abstract
738
Historical notes
738
Autoantigen
739
Autoantibody
741
Clinical utility
742
Conclusions
745
Take-home messages
745
References
746
Chapter 88 Anti-Collagen Antibodies
748
Abstract
748
Historical notes
748
Collagen as an autoantigen
749
Autoantibody
751
Clinical utility
752
Take-home messages
753
References
753
Chapter 89 Anti-Cyclic Citrullinated Peptide Antibody
756
Historical perspective
756
Antibody/antigen
756
Summary
758
References
758
Chapter 90 Anti-Endothelial Cell Autoantibodies
760
Abstract
760
Historical notes
761
Autoantigens
761
Autoantibodies
763
Clinical utility
765
Take-home messages
766
References
766
Chapter 91 Lupus Anticoagulant Testing
768
Abstract
768
Historical notes
769
Autoantigen
769
Autoantibody
770
Clinical utility
771
Take-home messages
773
References
773
Chapter 92 Anticardiolipin Antibodies
776
Abstract
776
Historical notes
776
Autoantigens
777
Autoantibodies
777
Clinical utility
779
Take-home messages
780
References
780
Chapter 93 Phospholipid Autoantibodies (Non-Anticardiolipin)–Anti-Prothrombin Antibodies
782
Abstract
782
Historical notes
782
Detection methods and immunological properties
783
Epitope mapping
784
Mechanisms of action
784
Pathophysiology of thrombosis and miscarriage
785
Clinical relevance
785
Treatment
786
Take-home messages
787
References
787
Chapter 94 Rheumatoid Factors
790
Abstract
790
Historical notes
790
Autoantigen
791
Autoantibodies
792
Clinical utility
795
Take-home messages
797
References
797
Part XIII Skin Disease Autoantibodies
798
Chapter 95 Autoantibodies to Mucocutaneous Antigens
800
Abstract
800
Historical notes
801
Type II Mucocutaneous autoimmunity: Epidermal antigens
803
Type II Mucocutaneous autoimmunity: Dermal antigens
809
Conclusion
812
Take-home messages
812
Acknowledgment
813
References
813
Part XIV Unique Clinical Situations
816
Chapter 96 Autoimmunity and the Newer Biopharmaceuticals
818
Abstract
818
Introduction
819
Toxicity profile and autoimmunity
820
Antinuclear, anti-dsDNA and anti-phospholipid antibodies
821
Possible mechanisms involved in the production of neutralising and non-neutralising autoantibodies during anti-TNF-alpha treatment
823
Conclusions
825
References
825
Chapter 97 Autoantibodies Against Tumor Suppressor Proteins
828
Abstract
828
Historical notes
829
Retinoblastoma (RB) gene
829
p16 gene
830
p73 gene
831
Conclusion
832
References
833
Chapter 98 Detection of Autoantibodies Using Protein Arrays
834
Abstract
834
Introduction
834
Early history
835
Preparation and optimal utilization of protein arrays
836
Application of protein arrays to autoimmunity
837
Protein arrays and proteomics
839
Conclusion
840
References
840
Chapter 99 Autoantibodies and Pregnancy Loss
844
Abstract
844
Historical notes
844
Autoantigens
845
Autoantibodies
845
Clinical utility
847
References
848
Part XV Future Directions
850
Chapter 100 Anti-Glycan Antibodies
852
Abstract
852
Glycan antigens
853
Anti-glycan antibodies in normal population
853
Anti-glycan antibodies in multiple sclerosis
854
Anti-glycan antibodies in inflammatory bowel disease
855
Take-home messages
856
References
857
Chapter 101 Future Trends
858
Abstract
858
The past
858
The Present
859
The Future
859
Take-home messages
860
References
860
Index
862
Color Plates
874
Alle Preise verstehen sich inklusive der gesetzlichen MwSt.