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CONTENTS
5
FOREWORD
11
PREFACE
14
The Early Earth
15
Reconstructing the Universal Tree of Life
29
The Nature of the Last G)mmon Ancestor
48
Ribozyme-Catalyzed Genetics
62
The Evolutionary History of the Translation Machinery
106
Functional Evolution of Ribosomes
120
Aminoacyi-tRNA Synthetases as Clues to Establishment of the Genetic Code
133
The Relation between Function, Structure and Evolution of Elongation Factors Tu
148
Origin and Evolution of DNA and DNA Replication Machineries
159
Early Evolution of DNA Repair Mechanisms
183
Extant Variations in the Genetic Code
197
Expanding the Genetic Code in Vitro and in Vivo
235
INDEX
264
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