IMRT, IGRT, SBRT

Cover

Contents

Preface

Introduction

Advances in the Planning and Delivery of Radiotherapy: New Expectations, New Standards of Care

Abstract

The Expansion of Radiation Oncology Technologies

Target Volume Specification and Treatment: Issues of Accuracy

Intensity-Modulated Radiation Therapy/Image-Guided Radiation Therapy Planning and Delivery Technologies: Current Challenges

Proton and Heavy Ion Radiation Therapy

Radiation Dose and Second Cancers

Radiation Oncology Informatics

Conclusions

References

General Concepts and Methods

Advanced Technologies in the Radiotherapy Clinic: System Fundamentals

Abstract

A Typical Intensity-Modulated Radiotherapy Treatment Planning System

Target Localization and Image Guidance

Image Registration

Adaptive Radiotherapy

References

Economic Perspectives

Controversies in the Adoption of New Healthcare Technologies

Abstract

Health Technology Assessment

Payment Policy Development: Past and Present Realities, and Future Uncertainties

Cost-Effectiveness Methodologies, Implications in an Era of Value-Based Purchasing

Conclusions

References

IMRT: Advances in Treatment Design and Delivery

Clinical Implementation of Intensity-Modulated Arc Therapy

Abstract

Intensity-Modulated Arc Therapy: Basic Concepts

Why Rotational Intensity-Modulated Radiation Therapy?

Commercial Intensity-Modulated Arc Therapy Solutions

Clinical Implementation of Intensity-Modulated Arc Therapy

References

IGRT: Advances in Targeting Therapy

4D Imaging and 4D Radiation Therapy: A New Era of Therapy Design and Delivery

Abstract

Impact of Breathing Motion on Images

Impact of Breathing Motion during Treatments

Methods to Account for Breathing Motion

Future Directions

Acknowledgements

References

Locating and Targeting Moving Tumors with Radiation Beams

Abstract

How Do We Locate the Moving Target?

How Do We Hit a Moving Target?

How Do We Create Integrated Systems to Locate and Hit Moving Targets?

Conclusions

References

Integrating IMRT and IGRT into Treatment Delivery

Technologies of Image Guidance and the Development of Advanced Linear Accelerator Systems for Radiotherapy

Abstract

Technologies to Meet the Goals of Image-Guided Radiation Therapy

Image Guidance Systems and Procedures

Cone-Beam CT for Linac-Based Image-Guided Radiation Therapy

Image Guidance: Meeting Future Needs

Conclusions

References

HelicalTomotherapy: Image-Guided and Adaptive Radiotherapy

Abstract

System Overview

Clinical Applications of Helical Tomotherapy

Daily Megavoltage-Based CT Imaging

Dose Evaluation and Adaptive Radiotherapy

Conclusions

References

The CyberKnife in Clinical Use: Current Roles, Future Expectations

Abstract

The CyberKnife System

Advances in CyberKnife Treatment Planning and Dose Delivery

Current Clinical Applications of CyberKnife

The Future of CyberKnife

References

Image Guidance and the New Practice of Radiotherapy: What to Know and Use from a Decade of Investigation

Abstract

The Rationale for Image-Guided Radiation Therapy: Perspectives on the Current Practice of Radiotherapy

Challenges in Image-Guided Radiation Therapy

Clinical Applications of Image-Guided Radiation Therapy

Adaptive Radiotherapy

Conclusions

References

Head and Neck Cancers

Intensity-Modulated and Image-Guided Radiation Therapy for Head and Neck Cancers

Abstract

Intensity-Modulated Radiation Therapy/Image-Guided Radiation Therapy Planning for Head and Neck Cancers

Intensity-Modulated Radiation Therapy for Nasopharyngeal Carcinomas

Intensity-Modulated Radiation Therapy for Oropharyngeal Carcinomas

Conclusions

Guidelines for Clinical Practice

References

Delineating Neck Targets for Intensity-Modulated Radiation Therapy of Head and Neck Cancer

Abstract

Tumor and Target Volumes in the Neck

Target Doses and Techniques

Case Studies

Guidelines for Clinical Practice

References

Thoracic Cancers

Motion Management and Image Guidance for Thoracic Tumor Radiotherapy: Clinical Treatment Programs

Abstract

Practical Strategies for Managing Respiratory Motion

Case Example: Clinical Procedures for Respiratory Gating

References

Breast Cancer

Intensity-Modulated Radiotherapy for Breast Cancer: Advances in Whole and Partial Breast Treatment

Abstract

Intensity-Modulated Radiotherapy and the Goals of Breast Radiotherapy

Improving Dose Homogeneity

Avoidance of Organs at Risk

Clinical Treatment Planning

Partial Breast Radiotherapy

Intensity-Modulated Radiotherapy and Partial Breast Irradiation

Guidelines for Clinical Practice

References

Abdominal Cancers

Image-Guided Radiotherapy Strategies in Upper Gastrointestinal Malignancies

Abstract

Immobilization and Motion Management in Upper Abdominal Malignancies

Image-Guided Radiotherapy for Pancreatic Cancer

Image-Guided Radiotherapy for Liver Cancer

Conclusions

Guidelines for Clinical Practice

Acknowledgements

References

Lymphomas

Radiotherapy Planning for the Lymphomas: Expanding Roles for Biologic Imaging

Abstract

Initial Staging

Response Evaluation

Radiation Therapy Planning

Clinical Trials Utilizing PET

Guidelines for Clinical Practice

References

Prostate Cancer

Image-Guided, Adaptive Radiotherapy of Prostate Cancer: Toward New Standards of Radiotherapy Practice

Abstract

Prostate Radiotherapy: A Model for Adaptive Image-Guided Radiotherapy

Dosimetric Impact of Motion in Prostate Radiotherapy

Solutions to Motion and Deformation in Prostate Image-Guided Radiotherapy

Guidelines for Clinical Practice

References

SBRT Advances

The Expanding Roles of Stereotactic Body Radiation Therapy and Oligofractionation: Toward a New Practice of Radiotherapy

Abstract

The Radiobiology of Stereotactic Body Radiation Therapy

Stereotactic Body Radiation Therapy Applications

Future Directions for Stereotactic Body Radiation Therapy

Conclusions

References

Stereotactic Body Radiation Therapy: Normal Tissue and Tumor Control Effects with Large Dose per Fraction

Abstract

Traditional Radiobiology

Modeling the Survival Curve

Biologically Equivalent Dose

Organ/Tissue Function and Microscopic Architecture

Serially Functioning Tissue Macroscopic Architecture

Stereotactic Body Radiation Therapy and Ablation

Normal Tissue Consequences of Ablative Dose Delivery

Tumor Control Dose

Conclusions

References

Thoracic Cancers

Stereotactic Body Radiation Therapy for Thoracic Cancers: Recommendations for Patient Selection, Setup and Therapy

Abstract

Prospective Testing of Stereotactic Body Radiation Therapy

A Guide to Stereotactic Body Radiation Therapy: Procedures and Practice

Guidelines for Clinical Practice

References

Gastrointestinal Cancers

Stereotactic Body Radiation Therapy for Gastrointestinal Malignancies

Abstract

Stereotactic Body Radiotherapy for Locally Advanced Pancreatic Cancers

Stereotactic Body Radiotherapy for Hepatic Malignancies

Guidelines for Clinical Practice

References

Genitourinary Cancers

Stereotactic Body Radiotherapy for Prostate Cancer: Current Results of a Phase II Trial

Abstract

Phase II Trial for Hypofractionated Radiotherapy of Prostate Cancer

Trial Results

Guidelines for Clinical Care

References

Techniques and Technologies

Proton Therapy: Clinical Gains through Current and Future Treatment Programs

Abstract

The State of the Art in Proton Therapy

Current and Future Developments in Clinical Proton Technology

Conclusions: Future Proton Technologies

References

Medical Applications and Advances

Proton Therapy in the Clinic

Abstract

Rationale for Protons

Protons: Clinical Advantages and Special Concerns

Proton Radiotherapy Treatment Planning

Issues in the Utilization of Proton Radiotherapy

Protons: Clinical Experience

Protons: How User Friendly?

Protons: Current Challenges

Guidelines for Clinical Practice

References

Author Index

Subject Index