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Foreword
5
Preface to the 2nd Edition
6
Preface to the 1st Edition
7
Contents
9
General Issues
12
Classification and Terminology
13
Requests for Imaging Using Contrast Agents: What Information Must be Provided
20
Off-Label Use of Medicines: Legal Aspects
24
Pharmacovigilance: When to Report Adverse Reactions
29
What is Required in Order to Get the Authorities to Approve a New Contrast Agent?
32
A Critical Review of Meta-Analysis of Adverse Events After Contrast Agents
37
Iodinated and Gadolinium Contrast Media
46
Prevention of Acute Reactions
47
Management of Acute Adverse Reactions
56
Iodinated and Gadolinium Contrast Media
64
Contrast Medium-Induced Nephropathy
65
Dialysis and Contrast Media
83
Non-Insulin-Dependent Diabetes and Contrast Media
88
Iodinated and Gadolinium Contrast Media
94
Pregnancy and Lactation
95
Phaeochromocytoma
102
Interactions with Other Drugs and Clinical Tests
105
Extravasation Injury
112
Iodinated Contrast Media
117
Late Adverse Reactions
118
Effects on the Blood and Endothelium
123
Effect on Thyroid Function
133
Pulmonary Effects
141
MRContrast Media
147
Chelates and Stability
148
Diagnostic Efficacy
154
Radiography with Gadolinium Contrast Agents
163
MR Contrast Media
170
Acute Adverse Reactions
171
Delayed Reactions: Nephrogenic Systemic Fibrosis
176
MR Contrast Media
186
Gadolinium-Based Contrast Agents
187
Non- Gadolinium-Based Contrast Agents
193
Ultrasonographic Contrast Media
201
Safety of Ultrasonographic Agents
202
Barium Preparations
207
Barium Preparations: Safety Issues
208
Appendix
212
ESUR Guidelines on Contrast Media
213
Official Publications from the European Society of Urogenital Radiology
227
Subject Index
228
List of Contributors
236
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