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Controversies in the Treatment of Lung Cancer
von: J. Heide, A. Schmittel, D. Kaiser, W. Hinkelbein
Karger, 2009
ISBN: 9783805592994 , 219 Seiten
Format: PDF, ePUB, OL
Kopierschutz: DRM
Preis: 251,09 EUR
Cover
1
Contents
6
Prognostic Factors in Histopathology ofLung Cancer
8
Abstract
8
Tumor Size: An Essential Prognostic Factor in Lung Cancer
10
Small Cell Lung Cancer
10
Prognosis and Predictive Factors in Small Cell Lung Cancer
11
Histological Subtype: A Prognostic Factor in NSCLC
12
Squamous Cell Carcinoma Histological Subtypes Associated with Poor Prognosis
12
Adenocarcinoma Histological Subtypes Associated with Poor Prognosis
13
Bronchioloalveolar Cell Carcinoma Growth Pattern: A Favorable Prognostic Factor
13
Large Cell Carcinomas
14
Prognostic Implication of Molecular Markers
15
Conclusion
19
References
20
FDG-PET/CT in Lung Cancer: An Update
22
Abstract
22
Non-Small Cell Lung Cancer
23
Staging of Lung Cancer – Distant Metastases
32
Prediction and Monitoring Response to Therapy
40
Pleural Metastases
42
Cost-Effectiveness
43
Small Cell Lung Cancer
44
References
44
Whole-Body Magnetic Resonance Imaging for Staging of Lung Cancer
53
Abstract
53
Technical Aspects of Whole-Body MRI
54
Staging of Lung Cancer Using Whole-Body MRI
54
Conclusions
60
References
60
Bronchoscopy/Endobronchial Ultrasound
62
Abstract
62
EBUS-TBNA: Technique
63
Clinical Results
65
Complications
67
Conclusion
67
References
68
New Developments in Videomediastinoscopy: Video-Assisted Mediastinoscopic Lymphadenectomy and Mediastinoscopic Ultrasound
70
Abstract
70
Methods
71
Results
71
Comments
74
Implications for Clinical Practice and Further Research
76
References
77
Resection in Stage I/II Non-Small Cell Lung Cancer
78
Abstract
78
Surgery in Stages I and II
79
Conclusion
82
References
82
Role of Mediastinal Lymph Node Dissection in Non-Small Cell Lung Cancer
85
Abstract
85
Surgical Technique of Systematic Lymph Node Dissection
86
Role of Nodal Involvement on Survival
88
Impact of Mediastinal Lymph Node Dissection on Operative Morbidity, Mortality and Quality of Life
88
Diagnostic Role of Mediastinal Lymph Node Dissection
89
Therapeutic Role of Mediastinal Lymph Node Dissection
90
Conclusion
91
References
91
Radiation Therapy for Early Stage (I/II) Non-Small Cell Lung Cancer
94
Abstract
94
Radiation Therapy alone in Early Non-Small Cell Lung Cancer
95
Avenues for an Improvement of RT Alone in Early NSCLC
98
References
99
Stereotactic Body Radiation Therapy for Early Non-Small Cell Lung Cancer
101
Abstract
101
Definitions of Stereotactic Body Radiation Therapy
102
Staging Procedures before SBRT
104
Implementation of Techniques in Clinical Routine
105
Biological Basis of Hypofractionated SBRT
108
Historical Aspects and Early Clinical Experience in SBRT of Lung Cancer
109
Clinical Experience
109
Follow-Up Recommendations
116
Future
117
References
117
Extended Surgical Resection in Stage III Non-Small Cell Lung Cancer
122
Abstract
122
Discussion of Stage-Related Treatment
123
Conclusions
127
References
127
Stage III: Definitive Chemoradiotherapy
129
Abstract
129
Optimization of Combined Radiotherapy and Chemotherapy
130
Which Chemotherapy and Radiotherapy Regimens Are Optimal for Concurrent Chemoradiotherapy?
133
How Do Comorbidities Influence the Performance of Concurrent Chemoradiotherapy?
137
References
139
Adjuvant Therapy in Early-Stage Non-Small Cell Lung Cancer
142
Abstract
142
Landmark Studies Concerning Adjuvant Platinum-Based Chemotherapy
143
Negative Studies
144
The LACE (Lung Adjuvant Cisplatin Evaluation) Meta-Analysis (table 2)
144
Adjuvant Chemotherapy and Stage (table 3)
145
Which Chemotherapy Combination?
147
Adjuvant Radiotherapy
147
Patient Selection and Predictive or Prognostic Factors
147
Neoadjuvant Chemotherapy
149
Conclusion
149
References
150
Postoperative Irradiation in Non-Small Cell Lung Cancer
152
Abstract
152
References
155
Altered Fractionation Schemes in Radiotherapy
157
Abstract
157
Hypofractionated Stereotactic Body Radiotherapy for NSCLC (Stage I)
158
Hyperfractionated Accelerated Radiotherapy for Stage III NSCLC
161
References
162
Chemotherapy of Advanced Non-Small Cell Lung Cancer
164
Abstract
164
Pemetrexed
165
Cisplatin- vs. Carboplatin-Based Chemotherapy
165
Elderly Patients and Patients with Reduced Performance Status
166
Customized Chemotherapy
166
Targeted Therapies
167
Maintenance Therapy
167
Systemic Chemotherapy in Patients Progressing after First-Line Chemotherapy
168
Assessment of Efficacy
168
References
169
Radiotherapy
171
Abstract
171
Clinical Manifestations of Advanced Lung Carcinoma
171
Palliative Potential of Radiotherapy
172
Treatment Strategies
174
References
178
Treatment of Limited Disease Small Cell Lung Cancer
180
Abstract
180
Thoracic Radiotherapy
181
Patient Selection
184
Future Perspectives
185
References
185
Radiochemotherapy in Extensive Disease Small Cell Lung Cancer ED-SCLC
187
Abstract
187
RT in ED-SCLC Trial
188
Future Approaches
191
Conclusions
192
References
192
Radiotherapy for Extensive Stage Small Cell Lung Cancer
194
Abstract
194
Introduction
194
Brain Metastases
195
Prophylactic Cranial Irradiation
195
Thoracic Radiotherapy
197
References
198
Controversies in the Treatment of Advanced Stages of Small Cell Lung Cancer
200
Abstract
200
First-Line Chemotherapy
200
Prophylactic Cranial Irradiation after First-Line Chemotherapy
202
Second-Line Chemotherapy
202
References
203
Complementary and Alternative Medicinein Lung Cancer Patients: A Neglected Phenomenon?
205
Abstract
205
Methods
207
Results
208
Discussion
209
Conclusions
210
References
211
Author Index
213
Subject Index
214
Back cover
219
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